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Hypoxia-derived oxidative stress mediates epigenetic repression of PKCɛ gene in foetal rat hearts
AIMS: Hypoxia causes protein kinase C epsilon (PKCɛ) gene repression in foetal hearts, resulting in heightened cardiac susceptibility to ischaemic injury in offspring. We tested the hypothesis that hypoxia inducible factor 1 (HIF-1) and/or reactive oxygen species (ROS) mediate hypoxia-induced PKCɛ g...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3258654/ https://ncbi.nlm.nih.gov/pubmed/22139554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr322 |
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