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Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases
Zinc-finger nucleases and TALE nucleases are produced by combining a specific DNA-binding module and a non-specific DNA-cleavage module, resulting in nucleases able to cleave DNA at a unique sequence. Here a new approach for creating highly specific nucleases was pursued by fusing a catalytically in...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3258161/ https://ncbi.nlm.nih.gov/pubmed/21965534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr788 |
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