Inhibition of Indoleamine 2,3-Dioxygenase Activity by Levo-1-Methyl Tryptophan Blocks Gamma Interferon-Induced Chlamydia trachomatis Persistence in Human Epithelial Cells

Gamma interferon (IFN-γ) induces expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial cells, the permissive cells for the obligate intracellular bacterium Chlamydia trachomatis. IDO1 depletes tryptophan by catabolizing it to kynurenine with conseque...

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Autores principales: Ibana, Joyce A., Belland, Robert J., Zea, Arnold H., Schust, Danny J., Nagamatsu, Takeshi, AbdelRahman, Yasser M., Tate, David J., Beatty, Wandy L., Aiyar, Ashok A., Quayle, Alison J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2011
Materias:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257928/
https://ncbi.nlm.nih.gov/pubmed/21911470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05659-11
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