Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila

Aging and age-related diseases can be viewed as the result of the lifelong accumulation of stress insults. The identification of mutant strains and genes which are responsive to stress and can alter longevity profiles provides new therapeutic targets for age-related diseases. Here we reported that a...

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Detalhes bibliográficos
Main Authors: Wang, Ching-Tzu, Chen, Yi-Chun, Wang, Yi-Yun, Huang, Ming-Hao, Yen, Tzu-Li, Li, Hsun, Liang, Cyong-Jhih, Sang, Tzu-Kang, Cho, Si-Chih, Yuh, Chiou-Hwa, Wang, Chao-Yung, Brummel, Theodore J., Wang, Horng-Dar
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257417/
https://ncbi.nlm.nih.gov/pubmed/22040003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00762.x
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