Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly

Aging is accompanied by a progressive decline in immune function. Studies have shown age-related decreases in the expression and signaling efficiency of Toll-like receptors (TLRs) in monocytes and dendritic cells and dysregulation of macrophage TLR3. Using a multivariable mixed effect model, we repo...

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Autors principals: Qian, Feng, Wang, Xiaomei, Zhang, Lin, Chen, Shu, Piecychna, Marta, Allore, Heather, Bockenstedt, Linda, Malawista, Stephen, Bucala, Richard, Shaw, Albert C, Fikrig, Erol, Montgomery, Ruth R
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2012
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257374/
https://ncbi.nlm.nih.gov/pubmed/22023165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00759.x
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