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Global Analysis of Small Molecule Binding to Related Protein Targets

We report on the integration of pharmacological data and homology information for a large scale analysis of small molecule binding to related targets. Differences in small molecule binding have been assessed for curated pairs of human to rat orthologs and also for recently diverged human paralogs. O...

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Autors principals: Kruger, Felix A., Overington, John P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257267/
https://ncbi.nlm.nih.gov/pubmed/22253582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002333
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