The Protein Kinase C Inhibitor Enzastaurin Exhibits Antitumor Activity against Uveal Melanoma

GNAQ mutations at codon 209 have been recently identified in approximately 50% of uveal melanomas (UM) and are reported to be oncogenic through activating the MAPK/Erk1/2 pathway. Protein kinase C (PKC) is a component of signaling from GNAQ to Erk1/2. Inhibition of PKC might regulate GNAQ mutation-i...

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Détails bibliographiques
Auteurs principaux: Wu, Xinqi, Zhu, Meijun, Fletcher, Jonathan A., Giobbie-Hurder, Anita, Hodi, F. Stephen
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257235/
https://ncbi.nlm.nih.gov/pubmed/22253748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029622
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