An RGS4-Mediated Phenotypic Switch of Bronchial Smooth Muscle Cells Promotes Fixed Airway Obstruction in Asthma

In severe asthma, bronchodilator- and steroid-insensitive airflow obstruction develops through unknown mechanisms characterized by increased lung airway smooth muscle (ASM) mass and stiffness. We explored the role of a Regulator of G-protein Signaling protein (RGS4) in the ASM hyperplasia and reduce...

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Hauptverfasser: Damera, Gautam, Druey, Kirk M., Cooper, Philip R., Krymskaya, Vera P., Soberman, Roy J., Amrani, Yassine, Hoshi, Toshinori, Brightling, Christopher E., Panettieri, Reynold A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257220/
https://ncbi.nlm.nih.gov/pubmed/22253691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028504
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