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Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity

BACKGROUND: It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon known as retroactivity. An important consequence of retroactivity, which arises due to enzyme sequestration in covalently...

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Bibliografski detalji
Glavni autori: Wynn, Michelle L, Ventura, Alejandra C, Sepulchre, Jacques A, García, Héctor J, Merajver, Sofia D
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257213/
https://ncbi.nlm.nih.gov/pubmed/21970676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-156
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