MicroRNA let-7c Suppresses Androgen Receptor Expression and Activity via Regulation of Myc Expression in Prostate Cancer Cells

Castration-resistant prostate cancer continues to rely on androgen receptor (AR) expression. AR plays a central role in the development of prostate cancer and progression to castration resistance during and after androgen deprivation therapy. Here, we identified miR-let-7c as a key regulator of expr...

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Autors principals: Nadiminty, Nagalakshmi, Tummala, Ramakumar, Lou, Wei, Zhu, Yezi, Zhang, Jin, Chen, Xinbin, deVere White, Ralph W., Kung, Hsing-Jien, Evans, Christopher P., Gao, Allen C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256915/
https://ncbi.nlm.nih.gov/pubmed/22128178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.278705
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