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Evidence for Irreversible Inhibition of Glycogen Synthase Kinase-3β by Tideglusib
Tideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy. Sustained oral administration of the compound to a variety of animal models decreases Tau hyperphosphorylation, lowers brain amyloid plaque load, improves...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3256883/ https://ncbi.nlm.nih.gov/pubmed/22102280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.306472 |
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