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Elucidation of Acid-induced Unfolding and Aggregation of Human Immunoglobulin IgG1 and IgG2 Fc

Understanding the underlying mechanisms of Fc aggregation is an important prerequisite for developing stable and efficacious antibody-based therapeutics. In our study, high resolution two-dimensional nuclear magnetic resonance (NMR) was employed to probe structural changes in the IgG1 Fc. A series o...

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Hlavní autoři: Latypov, Ramil F., Hogan, Sabine, Lau, Hollis, Gadgil, Himanshu, Liu, Dingjiang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256859/
https://ncbi.nlm.nih.gov/pubmed/22084250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.297697
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