Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells

Inhibition of mTOR signaling by rapamycin has been demonstrated to activate ERK1/2 and Akt in various types of cancer cells, which contributes to rapamycin resistance. However, the downstream effect of rapamycin-activated ERKs and Akt on survival or death substrate(s) remains unclear. We discovered...

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Bibliographic Details
Main Authors: Liu, Yan, Sun, Shi-Yong, Owonikoko, Taofeek K., Sica, Gabriel L., Curran, Walter J., Khuri, Fadlo R., Deng, Xingming
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256262/
https://ncbi.nlm.nih.gov/pubmed/22057915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0578
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