Protein Phosphatase 2A Mediates Dormancy of Glioblastoma Multiforme-Derived Tumor Stem-Like Cells during Hypoxia

PURPOSE: The hypoxic microenvironment of glioblastoma multiforme (GBM) is thought to increase resistance to cancer therapies. Recent evidence suggests that hypoxia induces protein phosphatase 2A (PP2A), a regulator of cell cycle and cell death. The effects of PP2A on GBM tumor cell proliferation and...

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Detalhes bibliográficos
Main Authors: Hofstetter, Christoph P., Burkhardt, Jan-Karl, Shin, Benjamin J., Gürsel, Demirkan B., Mubita, Lynn, Gorrepati, Ramana, Brennan, Cameron, Holland, Eric C., Boockvar, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256196/
https://ncbi.nlm.nih.gov/pubmed/22253878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030059
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