In Vitro Acquisition of Secondary Azole Resistance in Aspergillus fumigatus Isolates after Prolonged Exposure to Itraconazole: Presence of Heteroresistant Populations

Secondary resistance to azoles in Aspergillus fumigatus isolates from patients taking long-term itraconazole therapy has been described. We studied the acquisition of secondary azole resistance in 20 A. fumigatus isolates with no mutations at codon 54, 98, 138, 220, 432, or 448 in the cyp51A gene. A...

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Autors principals: Escribano, Pilar, Recio, Sandra, Peláez, Teresa, González-Rivera, Milagros, Bouza, Emilio, Guinea, Jesús
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256017/
https://ncbi.nlm.nih.gov/pubmed/22006000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00301-11
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