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Total Synthesis of the Spirocyclic Imine Marine Toxin (−)-Gymnodimine and an Unnatural C4-Epimer

The first total synthesis of the marine toxin (−)-gymnodimine (1) has been accomplished in a convergent manner. A highly diastereo- and enantioselective exo-Diels–Alder reaction catalyzed by a bis-oxazoline Cu(II) catalyst enabled rapid assembly of the spirocyclic core of gymnodimine. The preparatio...

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Detalhes bibliográficos
Main Authors: Kong, Ke, Moussa, Ziad, Lee, Changsuk, Romo, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256008/
https://ncbi.nlm.nih.gov/pubmed/22023219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja207385y
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