MET Amplification Identifies a Small and Aggressive Subgroup of Esophagogastric Adenocarcinoma With Evidence of Responsiveness to Crizotinib

PURPOSE: Amplification of the MET proto-oncogene in gastroesophageal cancer (GEC) may constitute a molecular marker for targeted therapy. We examined a GEC cohort with follow-up and reported the clinical response of four additional patients with MET-amplified tumors to the small molecule inhibitor c...

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Hlavní autoři: Lennerz, Jochen K., Kwak, Eunice L., Ackerman, Allison, Michael, Michael, Fox, Stephen B., Bergethon, Kristin, Lauwers, Gregory Y., Christensen, James G., Wilner, Keith D., Haber, Daniel A., Salgia, Ravi, Bang, Yung-Jue, Clark, Jeffrey W., Solomon, Benjamin J., Iafrate, A. John
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2011
Témata:
Original Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255989/
https://ncbi.nlm.nih.gov/pubmed/22042947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.35.4928
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