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Orphan Nuclear Receptor PNR/NR2E3 Stimulates p53 Functions by Enhancing p53 Acetylation

Since inactivation of tumor suppressor p53 functions is one of the most common features of human cancer cells, restoring p53 expression and activity is an important focus in cancer therapy. Here we report identification of photoreceptor-specific nuclear receptor (PNR)/NR2E3 as a positive regulator o...

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Autori principali: Wen, Zhi, Pyeon, Dohun, Wang, Yidan, Lambert, Paul, Xu, Wei, Ahlquist, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255696/
https://ncbi.nlm.nih.gov/pubmed/22025681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05513-11
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