The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium

Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear. Our previous work identified a previously unknown effect of VPA in reducing phosphoinositide production in the simple model Dictyostelium followed by the transfer of data to a...

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Detalhes bibliográficos
Main Authors: Chang, Pishan, Orabi, Benoit, Deranieh, Rania M., Dham, Manik, Hoeller, Oliver, Shimshoni, Jakob A., Yagen, Boris, Bialer, Meir, Greenberg, Miriam L., Walker, Matthew C., Williams, Robin S. B.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255550/
https://ncbi.nlm.nih.gov/pubmed/21876211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.008029
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