Conjugation of Organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and Indolo[3,2-d]benzazepines to Recombinant Human Serum Albumin: a Strategy To Enhance Cytotoxicity in Cancer Cells

[Image: see text] Following our strategy of coupling cyclin-dependent kinase (Cdk) inhibitors with organometallic moieties to improve their physicochemical properties and bioavailability, five organoruthenium complexes (1c–5c) of the general formula [RuCl(η(6)-arene)(L)]Cl have been synthesized in w...

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Hauptverfasser: Stepanenko, Iryna N., Casini, Angela, Edafe, Fabio, Novak, Maria S., Arion, Vladimir B., Dyson, Paul J., Jakupec, Michael A., Keppler, Bernhard K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2011
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255472/
https://ncbi.nlm.nih.gov/pubmed/22111668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic201801e
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