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Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation

1,2,4,5-Tetrazines have been established as effective dienes for inverse electron demand [4 + 2] Diels-Alder cycloaddition reactions with strained alkenes for over fifty years. Recently, this reaction pair combination has been applied to bioorthogonal labeling and cell detection applications; howeve...

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Detalles Bibliográficos
Main Authors: Karver, Mark R., Weissleder, Ralph, Hilderbrand, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254257/
https://ncbi.nlm.nih.gov/pubmed/21950520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200295y
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