Reversibility of replicative senescence in Saccharomyces cerevisiae: effect of homologous recombination and cell cycle checkpoints

Primary human somatic cells grown in culture divide a finite number of times, exhibiting progressive changes in metabolism and morphology before cessation of cycling. This telomere-initiated cellular senescence occurs because cells have halted production of telomerase, a DNA polymerase required for...

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Main Authors: Becerra, Sandra C., Thambugala, Hiranthi T., Erickson, Alison Russell, Lee, Christopher K., Lewis, L. Kevin
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253946/
https://ncbi.nlm.nih.gov/pubmed/22071150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.10.003
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