Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130 dependent manner accompanied by contractile dysfunction and ventricular arrhythmias

BACKGROUND: Suppressor of cytokine signaling-3 (SOCS3) is a key negative-feedback regulator of gp130 receptor that provides crucial signaling for cardiac hypertrophy and survival; however, an in vivo role of SOCS3 regulation on cardiac gp130 signaling remains obscure. METHODS AND RESULTS: We generat...

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Main Authors: Yajima, Toshitaka, Murofushi, Yoshiteru, Zhou, Hanbing, Park, Stanley, Housman, Jonathan, Zhong, Zhao-Hua, Nakamura, Michinari, Machida, Mitsuyo, Hwang, Kyung-Kuk, Gu, Yusu, Dalton, Nancy D., Yajima, Tomoko, Yasukawa, Hideo, Peterson, Kirk L, Knowlton, Kirk U.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253669/
https://ncbi.nlm.nih.gov/pubmed/22082679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.028498
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