Helix stabilization of amphipathic peptides by hydrocarbon stapling increases cholesterol efflux by the ABCA1 transporter

Apolipoprotein mimetic peptides are short amphipathic peptides that efflux cholesterol from cells by the ABCA1 transporter and are being investigated as therapeutic agents for cardiovascular disease. We examined the role of helix stabilization of these peptides in cholesterol efflux. A 23-amino acid...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sviridov, DO, Ikpot, IZ, Stonik, J, Drake, SK, Amar, M, Osei-Hwedieh, DO, Piszczek, G, Turner, S, Remaley, AT
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253552/
https://ncbi.nlm.nih.gov/pubmed/21672528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.05.154
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