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Binding features of steroidal and nonsteroidal inhibitors
Aromatase is the rate-limiting enzyme in estrogen biosynthesis. As a cytochrome P450, it utilizes electrons from NADPH–cytochrome P450 reductase (CPR) to produce estrogen from androgen. Estrogen is a key factor in the promotion of hormone-dependent breast cancer growth. Aromatase inhibitors (AIs) ar...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3253312/ https://ncbi.nlm.nih.gov/pubmed/21420422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2011.02.037 |
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