A New Derivative of Valproic Acid Amide Possesses a Broad-spectrum Antiseizure Profile and Unique Activity Against Status Epilepticus and Organophosphate Neuronal Damage

PURPOSE: sec-Butyl-propylacetamide (SPD) is a one-carbon homologue of valnoctamide (VCD), a CNS-active amide derivative of valproic acid (VPA) currently in phase II clinical trials. The current study evaluated the anticonvulsant activity of SPD in a battery of rodent seizure and epilepsy models and...

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Hlavní autoři: White, H. Steve, Alex, Anitha B., Pollock, Amanda, Hen, Naama, Shekh-Ahmad, Tawfeeq, Wilcox, Karen S., McDonough, John H., Stables, James P., Kaufmann, Dan, Yagen, Boris, Bialer, Meir
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253224/
https://ncbi.nlm.nih.gov/pubmed/22150444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1528-1167.2011.03338.x
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