Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans

Sle1a.1 is part of the Sle1 susceptibility locus, which has the strongest association with lupus nephritis in the NZM2410 mouse model. Here we show that Sle1a.1 results in the production of activated and autoreactive CD4(+) T cells. In addition, Sle1a.1 expression reduces the peripheral regulatory T...

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Detalhes bibliográficos
Main Authors: Cuda, Carla M., Li, Shiwu, Liang, Shujuan, Yin, Yiming, Potula, Hari Hara S.K., Xu, Zhiwei, Sengupta, Mayami, Chen, Yifang, Butfiloski, Edward, Baker, Henry, Chang, Lung-Ji, Dozmorov, Igor, Sobel, Eric S., Morel, Laurence
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253202/
https://ncbi.nlm.nih.gov/pubmed/22180614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002362
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