Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation

BACKGROUND: Pancreas cancer is one of most aggressive human cancers with the survival rate for patients with metastatic pancreas cancer at 5-6 months. The poor survival demonstrates a clear need for better target identification, drug development and new therapeutic strategies. Recent discoveries hav...

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Main Authors: Vo, Kevin, Amarasinghe, Barushi, Washington, Kay, Gonzalez, Adriana, Berlin, Jordan, Dang, Thao P
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253061/
https://ncbi.nlm.nih.gov/pubmed/22074495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-138
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