A critical step for JNK activation: isomerization by the prolyl isomerase Pin1

c-Jun N-terminal kinase (JNK) is activated by dual phosphorylation of both threonine and tyrosine residues in the phosphorylation loop of the protein in response to several stress factors. However, the precise molecular mechanisms for activation after phosphorylation remain elusive. Here we show tha...

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Detalhes bibliográficos
Main Authors: Park, J E, Lee, J A, Park, S G, Lee, D H, Kim, S J, Kim, H-J, Uchida, C, Uchida, T, Park, B C, Cho, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252824/
https://ncbi.nlm.nih.gov/pubmed/21660049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.82
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