ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry

A coding variant in ADH1B (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low allele frequencies the effects in European or African populations have been difficult to detect. We genotyped and anal...

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Main Authors: Bierut, Laura Jean, Goate, Alison M, Breslau, Naomi, Johnson, Eric O, Bertelsen, Sarah, Fox, Louis, Agrawal, Arpana, Bucholz, Kathleen K, Grucza, Richard, Hesselbrock, Victor, Kramer, John, Kuperman, Samuel, Nurnberger, John, Porjesz, Bernice, Saccone, Nancy L, Schuckit, Marc, Tischfield, Jay, Wang, Jen C, Foroud, Tatiana, Rice, John P, Edenberg, Howard J
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252425/
https://ncbi.nlm.nih.gov/pubmed/21968928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2011.124
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