GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity

BACKGROUND: Expression of insulin in terminally differentiated non-beta cell types in the pancreas could be important to treating type-1 diabetes. Previous findings led us to hypothesize involvement of kinase inhibition in induction of insulin expression in pancreatic alpha cells. METHODOLOGY/PRINCI...

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Detalhes bibliográficos
Principais autores: Fomina-Yadlin, Dina, Kubicek, Stefan, Vetere, Amedeo, He, Kaihui Hu, Schreiber, Stuart L., Wagner, Bridget K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252286/
https://ncbi.nlm.nih.gov/pubmed/22242153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028808
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