A Viral Dynamic Model for Treatment Regimens with Direct-acting Antivirals for Chronic Hepatitis C Infection

We propose an integrative, mechanistic model that integrates in vitro virology data, pharmacokinetics, and viral response to a combination regimen of a direct-acting antiviral (telaprevir, an HCV NS3-4A protease inhibitor) and peginterferon alfa-2a/ribavirin (PR) in patients with genotype 1 chronic...

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Autors principals: Adiwijaya, Bambang S., Kieffer, Tara L., Henshaw, Joshua, Eisenhauer, Karen, Kimko, Holly, Alam, John J., Kauffman, Robert S., Garg, Varun
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252270/
https://ncbi.nlm.nih.gov/pubmed/22241977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002339
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