Genome-Wide Assessment of AU-Rich Elements by the AREScore Algorithm

In mammalian cells, AU-rich elements (AREs) are well known regulatory sequences located in the 3′ untranslated region (UTR) of many short-lived mRNAs. AREs cause mRNAs to be degraded rapidly and thereby suppress gene expression at the posttranscriptional level. Based on the number of AUUUA pentamers...

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Main Authors: Spasic, Milan, Friedel, Caroline C., Schott, Johanna, Kreth, Jochen, Leppek, Kathrin, Hofmann, Sarah, Ozgur, Sevim, Stoecklin, Georg
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252268/
https://ncbi.nlm.nih.gov/pubmed/22242014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002433
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