Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1

BACKGROUND: Polymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence asthma risk in children. METHODS: In a previous analysis of 372 children f...

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Autori principali: Sordillo, Joanne E, Sharma, Sunita, Poon, Audrey, Lasky-Su, Jessica, Belanger, Kathleen, Milton, Donald K, Bracken, Michael B, Triche, Elizabeth W, Leaderer, Brian P, Gold, Diane R, Litonjua, Augusto A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252252/
https://ncbi.nlm.nih.gov/pubmed/22151743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-12-158
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