Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours

BACKGROUND: Dulanermin (rhApo2L/TRAIL) induces apoptosis by binding to death receptors DR4 and DR5, leading to caspase activation and subsequent cell death. A Phase1a trial evaluated the safety and tolerability of dulanermin in patients with advanced tumours. One aim was to develop and validate phar...

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Hlavní autoři: Pan, Y, Xu, R, Peach, M, Huang, C-P, Branstetter, D, Novotny, W, Herbst, R S, Eckhardt, S G, Holland, P M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251880/
https://ncbi.nlm.nih.gov/pubmed/22033270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.456
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