A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT

BACKGROUND: Treatment with epidermal growth factor receptor (EGFR) inhibitors can result in clinical response in non-small-cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) for some unselected patients. EGFR and KRAS mutation status, amplification of EGFR, or gene expression predi...

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Autors principals: Bryant, J L, Britson, J, Balko, J M, Willian, M, Timmons, R, Frolov, A, Black, E P
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Molecular Diagnostics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251842/
https://ncbi.nlm.nih.gov/pubmed/22045191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.465
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