Structure-Activity Relationships of Diastereomeric Lysine Ring Size Analogs of the Antimicrobial Peptide Gramicidin S: MECHANISM OF ACTION AND DISCRIMINATION BETWEEN BACTERIAL AND ANIMAL CELL MEMBRANES

Structure-activity relationships were examined in seven gramicidin S analogs in which the ring-expanded analog GS14 [cyclo-(VKLKVdYPLKVKLdYP)] is modified by enantiomeric inversions of its lysine residues. The conformation, amphiphilicity, and self-association propensity of these peptides were inves...

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Hlavní autoři: Prenner, Elmar J., Kiricsi, Monika, Jelokhani-Niaraki, Masood, Lewis, Ruthven N. A. H., Hodges, Robert S., McElhaney, Ronald N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251617/
https://ncbi.nlm.nih.gov/pubmed/15542606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M406509200
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