Arginine and Asymmetric Dimethylarginine in Puromycin Aminonucleoside-Induced Chronic Kidney Disease in the Rat

BACKGROUND/AIMS: Reduced renal L-arginine (L-Arg) synthesis/transport, induction of arginases and increased endogenous NOS inhibitor, asymmetric dimethylarginine (ADMA) will inhibit NO production. This study investigated pathways of L-Arg synthesis/uptake/utilization, ADMA degradation and oxidant/an...

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Autori principali: Chen, Gin-Fu, Moningka, Natasha C., Sasser, Jennifer M., Zharikov, Sergey, Cunningham, Mark, Tain, You-Lin, Schwartz, Idit F., Baylis, Chris
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2012
Soggetti:
Original Report: Laboratory Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251243/
https://ncbi.nlm.nih.gov/pubmed/22179117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000334740
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