The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells

Inflammatory responses initiate rapid production of IL-1 family cytokines, including IL-18. This cytokine is produced at high levels in inflammatory diseases, including allergy and autoimmunity, and is known to induce IgE production in mice. Here we provide evidence that IL-18 is directly coupled to...

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Main Authors: Enoksson, Sara Lind, Grasset, Emilie K., Hägglöf, Thomas, Mattsson, Nina, Kaiser, Ylva, Gabrielsson, Susanne, McGaha, Tracy L., Scheynius, Annika, Karlsson, Mikael C. I.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251096/
https://ncbi.nlm.nih.gov/pubmed/22135456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107830108
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