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P-glycoprotein at the blood-brain barrier: kinetic modeling of (11)C-desmethylloperamide in mice using a (18)F-FDG μPET scan to determine the input function
PURPOSE: The objective of this study is the implementation of a kinetic model for (11)C-desmethylloperamide ((11)C-dLop) and the determination of a typical parameter for P-glycoprotein (P-gp) functionality in mice. Since arterial blood sampling in mice is difficult, an alternative method to obtain t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3250994/ https://ncbi.nlm.nih.gov/pubmed/22214199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-219X-1-12 |
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