Hu.4-1BB-Fc fusion protein inhibits allergic inflammation and airway hyperresponsiveness in a murine model of asthma

PURPOSE: 4-1BB (CD 137) is a costimulatory molecule expressed on activated T-cells. Repression by 4-1BB is thought to attenuate Th2-mediated allergic reactions. The aim of this study was to investigate the effect of 4-1BB on allergic airway inflammation in a murine asthma model. METHODS: BALB/c mice...

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Hlavní autoři: Kim, Byoung-Ju, Kwon, Ji-Won, Seo, Ju-Hee, Choi, Won-Ah, Kim, Young-Jun, Kang, Mi-Jin, Yu, Jinho, Hong, Soo-Jong
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Pediatric Society 2011
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250603/
https://ncbi.nlm.nih.gov/pubmed/22232630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3345/kjp.2011.54.9.373
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