A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

We report the involvement of an evolutionarily conserved set of mycobacterial genes, the esx-3 region, in evasion of bacterial killing by innate immunity. Whereas high-dose intravenous infections of mice with the rapidly growing mycobacterial species Mycobacterium smegmatis bearing an intact esx-3 l...

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Detalhes bibliográficos
Main Authors: Sweeney, Kari A, Dao, Dee N, Goldberg, Michael F, Hsu, Tsungda, Venkataswamy, Manjunatha M, Henao-Tamayo, Marcela, Ordway, Diane, Sellers, Rani S, Jain, Paras, Chen, Bing, Chen, Mei, Kim, John, Lukose, Regy, Chan, John, Orme, Ian M, Porcelli, Steven A, Jacobs, William R
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250071/
https://ncbi.nlm.nih.gov/pubmed/21892180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2420
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