Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo

Results from retrospective studies on the relationship between cytochrome P450 (P450) 2B6 (CYP2B6) genotype and cyclophosphamide (CY) efficacy and toxicity in adult cancer patients have been conflicting. We evaluated this relationship in children, who have faster CY clearance and receive different C...

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Главные авторы: Raccor, Brianne S., Claessens, Adam J., Dinh, Jean C., Park, Julie R., Hawkins, Douglas S., Thomas, Sushma S., Makar, Karen W., McCune, Jeannine S., Totah, Rheem A.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250049/
https://ncbi.nlm.nih.gov/pubmed/21976622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.039347
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