Hepatoprotective effects of select water–soluble PARP inhibitors in a carbon tetrachloride model

BACKGROUND: Inhibitors of the nuclear enzyme poly (ADP-ribose) polymerase (PARP-1) have been demonstrated to attenuate pathophysiologic conditions associated with oxidative stress, specifically with carbon tetrachloride (CT)-induced hepatotoxicity. SETTINGS AND DESIGN: In this investigation, we eval...

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Main Authors: McCluskey, James D, Sava, Dmytro, Harbison, Stephen C, Muro-Cacho, Carlos A, Giffe, Johnson T, Ping, Xu, Harbison, Raymond D
Format: Artigo
Jezik:Inglês
Izdano: Medknow Publications & Media Pvt Ltd 2011
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249858/
https://ncbi.nlm.nih.gov/pubmed/22229131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/2229-5151.84788
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