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Formulation and Optimization of Mucoadhesive Nanodrug Delivery System of Acyclovir
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infections, with an oral bioavailability of only 10–20% [limiting absorption in gastrointestinal tract to duodenum and jejunum] and half-life of about 3 h, and is soluble only at acidic pH (pKa 2.27). Mucoadhesive polymeri...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Medknow Publications & Media Pvt Ltd
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249739/ https://ncbi.nlm.nih.gov/pubmed/22224033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0975-1483.90236 |
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