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Toxicity as a Biomarker of Efficacy of Molecular Targeted Therapies: Focus on EGFR and VEGF Inhibiting Anticancer Drugs
In addition to being present in tumor cells, many targets of signal transduction inhibitors are also found in normal tissue. Side effects attributable to the mechanism of action of molecular targeted agents thus represent “on-target” modulation in normal tissues. These mechanism-based toxicities can...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
AlphaMed Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248772/ https://ncbi.nlm.nih.gov/pubmed/22135123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0163 |
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