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Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis
Glycogenin initiates the synthesis of a maltosaccharide chain covalently attached to itself on Tyr195 via a stepwise glucosylation reaction, priming glycogen synthesis. We have captured crystallographic snapshots of human glycogenin during its reaction cycle, revealing a dynamic conformational switc...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248551/ https://ncbi.nlm.nih.gov/pubmed/22160680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113921108 |
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