Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis

Glycogenin initiates the synthesis of a maltosaccharide chain covalently attached to itself on Tyr195 via a stepwise glucosylation reaction, priming glycogen synthesis. We have captured crystallographic snapshots of human glycogenin during its reaction cycle, revealing a dynamic conformational switc...

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Bibliographic Details
Main Authors: Chaikuad, Apirat, Froese, D. Sean, Berridge, Georgina, von Delft, Frank, Oppermann, Udo, Yue, Wyatt W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248551/
https://ncbi.nlm.nih.gov/pubmed/22160680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113921108
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