The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF

The Caenorhabditis elegans class A and B synthetic multivulva (synMuv) genes redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. We identify a class A synMuv mutation in the promoter of the lin-3 EGF gene, establishing that lin-3 is the key biological target of the class A...

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Main Authors: Saffer, Adam M., Kim, Dong Hyun, van Oudenaarden, Alexander, Horvitz, H. Robert
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248470/
https://ncbi.nlm.nih.gov/pubmed/22242000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002418
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