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Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals

Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation determines the phenotype of highly heritable traits such as height is uncertain...

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Autors principals: Chan, Yingleong, Holmen, Oddgeir L., Dauber, Andrew, Vatten, Lars, Havulinna, Aki S., Skorpen, Frank, Kvaløy, Kirsti, Silander, Kaisa, Nguyen, Thutrang T., Willer, Cristen, Boehnke, Michael, Perola, Markus, Palotie, Aarno, Salomaa, Veikko, Hveem, Kristian, Frayling, Timothy M., Hirschhorn, Joel N., Weedon, Michael N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248463/
https://ncbi.nlm.nih.gov/pubmed/22242009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002439
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