Ablation of Mrds1/Ofcc1 Induces Hyper-γ-Glutamyl Transpeptidasemia without Abnormal Head Development and Schizophrenia-Relevant Behaviors in Mice

Mutations in the Opo gene result in eye malformation in medaka fish. The human ortholog of this gene, MRDS1/OFCC1, is a potentially causal gene for orofacial cleft, as well as a susceptibility gene for schizophrenia, a devastating mental illness. Based on this evidence, we hypothesized that this gen...

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Autors principals: Ohnishi, Tetsuo, Yamada, Kazuo, Watanabe, Akiko, Ohba, Hisako, Sakaguchi, Toru, Honma, Yota, Iwayama, Yoshimi, Toyota, Tomoko, Maekawa, Motoko, Watanabe, Kazutada, Detera-Wadleigh, Sevilla D., Wakana, Shigeharu, Yoshikawa, Takeo
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248446/
https://ncbi.nlm.nih.gov/pubmed/22242126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029499
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